New research is being launched to determine what is the optimal gap between the doses of the coronavirus vaccine for pregnant women. Scientists hope that the results of the research will reassure mothers-to-be about the safety of the vaccine.
Researchers The trial aims to recruit more than 600 pregnant women to monitor the effectiveness of the vaccine and track the development of children under one year old.
The product was released less than a week after studies showed that the vast majority of pregnant women admitted to the hospital for Covid-19 were not vaccinated.
The chief midwife in England has written to general practitioners and other midwives across the country urging them to encourage mothers-to-be to get vaccinated.
We have good data and provide some security guarantees, but what we want to pursue is top-notch, high-quality data
The behind-the-scenes of this latest Preg-CoV trial said that although there are currently no safety issues when pregnant women receive Covid-19 injections, they hope that this will give pregnant women and those caring for them “the highest quality data on these vaccines”.
So far, nearly 52,000 pregnant women in England have been vaccinated-no safety issues have been reported.
This trial is the UK’s largest trial investigating the best gap between the first and second doses of pregnant women. It involves 7.5 million pounds of government funding and is led by St George’s. University London.
Professor Paul Heath, principal investigator and professor of pediatric infectious diseases at St. George’s University, said: “The current coverage (absorption) of vaccination during pregnancy is disappointing, very low, less than one-third.
“I suspect that one of the reasons for this is that they don’t have enough confidence in vaccination. Maybe participating in the trial will give them that confidence.”
He said that the lesson he hopes to learn from the pandemic is that “pregnant women need to be included in vaccine trials at an early stage,” and acknowledged that such trials “may have started six months ago.”
Professor Asma Khalil, the lead obstetrician for the trial and professor of obstetrics and maternal-fetal medicine at St. George’s Hospital, said that the most common question for pregnant women is whether they should be vaccinated.
She said that although there are data showing that pregnant women have no safety issues after being vaccinated, patients are still worried because pregnant women were not included in the initial Covid-19 vaccine trial.
She said: “We have very good data and provide some safety guarantees, but what we want to pursue is the highest quality. The trial will provide high-quality data from randomized controlled trials.”
vaccine Initially, Pfizer/BioNTech and Moderna vaccines will be involved, but other new vaccines will be included when they are approved in the future.
female If pregnancy is 13 to 34 weeks at the time of vaccination, children between 18 and 44 years old will be recruited from approximately 15 locations in England.
They will receive a vaccine randomly at a dosing interval of 4 to 6 weeks or a longer dosing interval of 8 to 12 weeks.
The results of the first trial, focusing on any adverse events after the first administration, should be announced before the end of the year, and the immune response results are expected to be announced in the first quarter of next year.
Dr Pat O’Brien, associate dean of the Royal College of Obstetricians and Gynecologists, said the results of this study may be relevant “for many years to come.”
He said: “This is an important study. We are satisfied with the safety of these vaccines. What we want to understand now is how to fine-tune them to better understand how they work. Give them the best. What is the way?
“Are they as effective for pregnant women as others? Remember, this epidemic is likely to become an endemic epidemic, and this situation may continue. Therefore, I suspect that the results of this trial will be relevant to us , Related to pregnant women for many years to come.”
I encourage anyone who is pregnant and eligible to sign up and contribute to research that can save lives in the coming years
Minister of Vaccines Nadim Zahavi Said: “Pregnant women are more likely to be seriously ill due to Covid-19. We know that the vaccine is safe for them and will have a huge impact-in fact, no pregnant women who have received two injections need to be hospitalized for Covid-19. .
“This government-supported trial will provide more data on how we can best protect pregnant women and their babies, and we can use this evidence to inform future vaccination plans.
“I encourage anyone who is pregnant and eligible to sign up and contribute to research that can save lives in the coming years.”
Last week, researchers at the University of Oxford described the results of their work as “worrying”, saying that one in 10 pregnant women admitted to hospital with Covid-19 symptoms often requires intensive care.
Mary Annette, professor of maternal and infant population health at the Nuffield Department of Population Health at Oxford University and the lead researcher of the study, said that pregnant women can “rest assured” about the safety of the vaccine and that antibodies will be passed on to pregnant women. Their baby.
